A Review of Dementia with Lewy Bodies' Impact, Diagnostic Criteria and Treatment
نویسندگان
چکیده
منابع مشابه
Diagnostic accuracy of dementia with Lewy bodies.
BACKGROUND Diagnostic criteria for dementia with Lewy bodies (DLB) are still evolving. No data exist on prospective differentiation of DLB and Alzheimer disease (AD). OBJECTIVE To examine the clinician's diagnostic accuracy for DLB and analyze factors contributing to false-positive DLB diagnoses. METHODS A prospective series of 10 patients with clinically diagnosed DLB who came to autopsy w...
متن کاملDementia with lewy bodies--diagnosis and treatment.
Dementia with Lewy bodies (DLB) accounts for 15-20% of all autopsy confirmed dementias in old age. Characteristic histopathological changes are intracellular Lewy bodies and Lewy neurites, with abundant senile plaques but sparse neurofibrillary tangles. Core clinical features are fluctuating cognitive impairment, persistent visual hallucinations and extrapyramidal motor symptoms (parkinsonism)....
متن کاملDementia with Lewy bodies.
The advent of new immunostains have improved the ability to detect limbic and cortical Lewy bodies, and it is evident that dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer's disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen symptoms and those that may improve them. Neuroc...
متن کاملDementia with Lewy bodies.
Dementia with Lewy bodies (DLB) is the second most common diagnosis of dementia after Alzheimer disease (AD). The essential pathologic feature is the Lewy body, a neuronal inclusion containing α-synuclein, found in brainstem nuclei and the neocortex. Clinical features include early fluctuations in attention, hallucinations, and parkinsonism, with progression to a combined cortical and subcortic...
متن کاملDementia with Lewy bodies.
In the last decade, a new degenerative dementia, probably the second most common after Alzheimer's disease (AD), has been increasingly recognized under the consensus name of dementia with Lewy bodies (DLB). This article reviews current clinical, genetic, and pathological DLB data and indicates directions for future research. DLB overlaps in clinical, pathological, and genetic features with AD a...
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ژورنال
عنوان ژورنال: Neurology and Therapy
سال: 2018
ISSN: 2193-8253,2193-6536
DOI: 10.1007/s40120-018-0104-1